منابع مشابه
Mechano-electric Feedback and Initiation of Cardiac Arrhythmias
The heart beat is controlled by electrical excitation waves which propagate through the heart and initiate cardiac contraction. Contraction of the heart also affects the process of wave propagation resulting in a complex global feedback phenomenon known as mechanoelectrical feedback (MEF). MEF has been studied in electrophysiology for well over a century and may have both pro-arrhythmic and arr...
متن کاملMechano-electric feedback.
From humble beginnings, cardiac mechanoelectric transduction or feedback has come of age. The last editorial board (Editor-in-Chief, David Hearse, and concerning the Focussed Issue particularly Associate Editor Michael Shattock) facilitated growth by encouraging the Issue. The present board (Editor-in-Chief, Michiel Janse, and concerning this focussed publication, Associate Editor Tobias Opthof...
متن کاملMechano-Electric Feedback in the Fish Heart
BACKGROUND Mechanoelectric feedback (MEF) describes the modulation of electrical activity by mechanical activity. This may occur via the activation of mechanosensitive ion channels (MSCs). MEF has not previously been investigated in fish ventricular tissue even though fish can greatly increase ventricular end diastolic volume during exercise which should therefore provide a powerful mechanical ...
متن کاملCardiac Mechano-Gated Ion Channels and Arrhythmias.
Mechanical forces will have been omnipresent since the origin of life, and living organisms have evolved mechanisms to sense, interpret, and respond to mechanical stimuli. The cardiovascular system in general, and the heart in particular, is exposed to constantly changing mechanical signals, including stretch, compression, bending, and shear. The heart adjusts its performance to the mechanical ...
متن کاملRabbit models of cardiac mechano-electric and mechano-mechanical coupling
Cardiac auto-regulation involves integrated regulatory loops linking electrics and mechanics in the heart. Whereas mechanical activity is usually seen as 'the endpoint' of cardiac auto-regulation, it is important to appreciate that the heart would not function without feed-back from the mechanical environment to cardiac electrical (mechano-electric coupling, MEC) and mechanical (mechano-mechani...
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ژورنال
عنوان ژورنال: Progress in Biophysics and Molecular Biology
سال: 2003
ISSN: 0079-6107
DOI: 10.1016/s0079-6107(03)00026-9